Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome
نویسندگان
چکیده
منابع مشابه
Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome.
RATIONALE The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown. OBJECTIVES Children with CHS hypoventilate during sleep, although they generally breathe adequately during wakefulness. Previous studies suggest that they have compromised central integration of afferent stimuli, rather than abnormal sensors or receptors. Co...
متن کاملDecreased cortical thickness in central hypoventilation syndrome.
Central hypoventilation syndrome (CHS) is a rare condition characterized by hypoventilation during sleep, reduced ventilatory responsiveness to CO(2) and O(2), impaired perception of air hunger, and autonomic abnormalities. Neural impairments accompany the condition, including structural injury, impaired cerebral autoregulation, and dysfunctional autonomic control. The hypoventilation may induc...
متن کامل24-hour BP in children with congenital central hypoventilation syndrome.
OBJECTIVE To study circadian BP patterns in patients with congenital central hypoventilation syndrome (CCHS). DESIGN Case-control study. SETTING Teaching hospital in Paris, France. PATIENTS Eleven patients with CCHS (median age, 13 years; range, 6 to 18 years) and 11 sex- and height-matched control subjects. INTERVENTION None. METHODS Each subject underwent 24-h ambulatory BP monitori...
متن کاملRespiratory and autonomic dysfunction in congenital central hypoventilation syndrome.
The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e., the mechanism by which brain Pco2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (...
متن کاملCongenital central hypoventilation syndrome
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of the automatic control of breathing. The literary misnomer "Ondine's curse" has been used in prior literatures and the disease was first described in 1970 by Mellins et al.1 The hallmark of the disease is alveolar hypoventilation with insensitivity to hypoxaemia and hypercapnia, most pronounced during sleep, but the clinica...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2008
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200804-606oc